Delivery of cefotaxime to the brain via intranasal administration
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چکیده
منابع مشابه
Intranasal delivery of cells to the brain.
The safety and efficacy of cell-based therapies for neurodegenerative diseases depends on the mode of cell administration. We hypothesized that intranasally administered cells could bypass the blood-brain barrier by migrating from the nasal mucosa through the cribriform plate along the olfactory neural pathway into the brain and cerebrospinal fluid (CSF). This would minimize or eliminate the di...
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As the people have been suffering from many CNS disorders like Multiple sclerosis, Alzheimer’s disease, Parkinson’s disease many drugs have been developed but they failed in showing the concentration required for action. But nose to brain drug delivery the drug directly enter into the brain. The objective of this review is to provide overview of nose on an physiological, anatomical and, barrier...
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The currently available antiepileptic drugs are typically administered via oral or intravenous (IV) routes which commonly exhibit high systemic distribution into non-targeted tissues, leading to peripheral adverse effects and limited brain uptake. In order to improve the efficacy and tolerability of the antiepileptic drug therapy, alternative administration strategies have been investigated. Th...
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The blood brain barrier (BBB) represents one of the strictest barriers of in vivo therapeutic drug delivery. The barrier is defined by restricted exchange of hydrophilic compounds, small proteins and charged molecules between the plasma and central nervous system (CNS). For decades, the BBB has prevented the use of many therapeutic agents for treating Alzheimer’s disease, stroke, brain tumor, h...
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The treatment of brain disorders is one of the greatest challenges in drug delivery because of a variety of main barriers in effective drug transport and maintaining therapeutic concentrations in the brain for a prolonged period. The objective of this study was delivery of valproic acid (VPA) to the brain by intranasal route. For this purpose, nanostructured lipid carriers (NLCs) were prepared ...
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ژورنال
عنوان ژورنال: Drug Development and Industrial Pharmacy
سال: 2011
ISSN: 0363-9045,1520-5762
DOI: 10.3109/03639045.2011.571696